I’m on vacation the next week and a half in the Republic of China — catching a glimpse of the inauguration of Taiwan’s next president William Lai, but mostly just eating and drinking my way from night market to night market. Normal newsletter columns will return in a few weeks, and we have the Riskgaming podcast all set and locked in the meantime (if you aren’t subscribed, what are you waiting for?).
Thanks as ever for reading.
Podcast: The soon-to-be-solved protein problem that will accelerate drug discovery
We’ve known for decades that one of the key mechanisms of biology — and of life itself — is the binding of molecules to proteins. Once bound, proteins change shape and thus their function, allowing our bodies to adapt and change their molecular machinery as needed for survival. The challenge that remains unsolved is to predict — across billions of potential proteins and a similar number of molecules — how those proteins change and how they might interact with each other.
The fervent hope of many scientists and entrepreneurs is that artificial intelligence coupled with experimental and synthetic datasets, may finally unlock this critical piece of the biological puzzle, ushering in a new wave of therapeutics.
My guest today is one of those science entrepreneurs, Laksh Aithani, the co-founder and CEO of Charm Therapeutics. He’s made cancer the focus of his work, and through Charm and his team, is building expansive datasets to develop AI models that can predict the 3D shape of proteins.
Alongside my Lux colleague Tess van Stekelenburg, we explore protein folding’s past, present and future, the utility and risks of synthetic data in biological research, how much money and time we might expect for future drug discovery, what individualized medicine might look like decades from now, and how new grads can get into the field as the century of biology kicks off.
One blockbuster piece this past week comes courtesy of Australia, where a Chinese spy has defected and spilled the tea on the country’s overseas intelligence and disruption operations. “The unit is called the Political Security Protection Bureau, or the 1st Bureau. It is one of the Chinese Communist Party's (CCP) key tools of repression, operating across the globe to surveil, kidnap and silence critics of the party, particularly President Xi Jinping. ‘It is the darkest department of the Chinese government,’ Eric said. ‘When dealing with people who oppose the CCP, they can behave as if these people are not protected by the law. They can do whatever they want to them.’”
Our former Lux editorial associate Ken Bui recommends Francis J. Gavin’s lead essay for the Texas National Security Review, "Cracks in the Ivory Tower?” “Erasmus loathed conflict, loved peace, and preached tolerance. He was, however, a moderate in an extreme age, disliked and mocked both by the reactionaries within the Church and the reformers from without. It goes without saying that our current world could use more figures in Erasmus’ mold.”
Following up on our podcast episode from two weeks ago (“Margaret Mead and the psychedelic community that theorized AI”), our scientist-in-residence Sam Arbesman recommends Benjamin Breen’s new essay, “LLM-based educational games will be a big deal.”Discussions of LLMs in education so far have tended to fixate on students using ChatGPT to cheat on assignments. Yet in my own experience, I’ve found them to be amazingly fertile tools for self-directed learning. GPT-4 has helped me learn colloquial expressions in Farsi, write basic Python scripts, game out possible questions for oral history interviews, translate and summarize historical sources, and develop dozens of different personae for my world history students to use for an in-class activity where they role-played as ancient Roman townsfolk.”
Nami Matsuura has a nice piece in Nikkei Asia on how “Robot sommeliers and baristas go to work in labor-starved South Korea.” “Last month in Seoul, [Doosan Robotics] began testing a barista robot that can pour 80 cups of coffee an hour and make latte art in partnership with a local cafe chain. It also tested a cooking robot that can run six deep-frying baskets at the same time at a high school, serving 500 people in two hours. … South Korea leads the world in robot density, with 1,012 robots for every 10,000 workers as of 2022, the International Federation of Robotics reports. The figure is well above second-ranked Singapore's 730, and double or triple the numbers in Germany, Japan, China and the U.S.”
Finally, Sam recommends the always cerebral Paul Ford’s sardonic new essay in Wired, "Generative AI Is Totally Shameless. I Want to Be It.” “Hilariously, the makers of ChatGPT—AI people in general—keep trying to teach these systems shame, in the form of special preambles, rules, guidance (don’t draw everyone as a white person, avoid racist language), which of course leads to armies of dorks trying to make the bot say racist things and screenshotting the results. But the current crop of AI leadership is absolutely unsuited to this work. They are themselves shameless, grasping at venture capital and talking about how their products will run the world, asking for billions or even trillions in investment. They insist we remake civilization around them and promise it will work out. But how are they going to teach a computer to behave if they can’t?”
That’s it, folks. Have questions, comments, or ideas? This newsletter is sent from my email, so you can just click reply.
Forcing China’s AI researchers to strive for chip efficiency will ultimately shave America’s lead
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Right now, pathbreaking AI foundation models follow an inverse Moore’s law (sometimes quipped “Eroom’s Law”). Each new generation is becoming more and more expensive to train as researchers exponentially increase the number of parameters used and overall model complexity. Sam Altman of OpenAI said that the cost of training GPT-4 was over $100 million, and some AI computational specialists believe that the first $1 billion model is currently or will shortly be developed.
As semiconductor chips rise in complexity, costs come down because transistors are packed more densely on silicon, cutting the cost per transistor during fabrication as well as lowering operational costs for energy and heat dissipation. That miracle of performance is the inverse with AI today. To increase the complexity (and therefore hopefully quality) of an AI model, researchers have attempted to pack in more and more parameters, each one of which demands more computation both for training and for usage. A 1 million parameter model can be trained for a few bucks and run on a $15 Raspberry Pi Zero 2 W, but Google’s PaLM with 540 billion parameters requires full-scale data centers to operate and is estimated to have cost millions of dollars to train.
Admittedly, simply having more parameters isn’t a magic recipe for better AI end performance. One recalls Steve Jobs’s marketing of the so-called “Megahertz Myth” to attempt to persuade the public that headline megahertz numbers weren't the right way to judge the performance of a personal computer. Performance in most fields is a complicated problem to judge, and just adding more inputs doesn't necessarily translate into a better output.
And indeed, there is an efficiency curve underway in AI outside of the leading-edge foundation models from OpenAI and Google. Researchers over the past two years have discovered better training techniques (as well as recipes to bundle these techniques together), developed best practices for spending on reinforcement learning from human feedback (RLHF), and curated better training data to improve model quality even while shaving parameter counts. Far from surpassing $1 billion, training new models that are equally performant might well cost only tens or hundreds of thousands of dollars.
This AI performance envelope between dollars invested and quality of model trained is a huge area of debate for the trajectory of the field (and was the most important theme to emanate from our AI Summit). And it’s absolutely vital to understand, since where the efficiency story ends up will determine the sustained market structure of the AI industry.
If foundation models cost billions of dollars to train, all the value and leverage of AI will accrue and centralize to the big tech companies like Microsoft (through OpenAI), Google and others who have the means and teams to lavish. But if the performance envelope reaches a significantly better dollar-to-quality ratio in the future, that means the whole field opens up to startups and novel experiments, while the leverage of the big tech companies would be much reduced.
The U.S. right now is parallelizing both approaches toward AI. Big tech is hurling billions of dollars on the field, while startups are exploring and developing more efficient models given their relatively meagre resources and limited access to Nvidia’s flagship chip, the H100. Talent — on balance — is heading as it typically does to big tech. Why work on efficiency when a big tech behemoth has money to burn on theoretical ideas emanating from university AI labs?
Without access to the highest-performance chips, China is limited in the work it can do on the cutting-edge frontiers of AI development. Without more chips (and in the future, the next generations of GPUs), it won’t have the competitive compute power to push the AI field to its limits like American companies. That leaves China with the only other path available, which is to follow the parallel course for improving AI through efficiency.
For those looking to prevent the decline of American economic power, this is an alarming development. Model efficiency is what will ultimately allow foundation models to be preloaded onto our devices and open up the consumer market to cheap and rapid AI interactions. Whoever builds an advantage in model efficiency will open up a range of applications that remain impractical or too expensive for the most complex AI models.
Given U.S. export controls, China is now (by assumption, and yes, it’s a big assumption) putting its entire weight behind building the AI models it can, which are focused on efficiency. Which means that its resources are arrayed for building the platforms to capture end-user applications — the exact opposite goal of American policymakers. It’s a classic result: restricting access to technology forces engineers to be more creative in building their products, the exact intensified creativity that typically leads to the next great startup or scientific breakthrough.
If America was serious about slowing the growth of China’s still-nascent semiconductor market, it really should have taken a page from the Chinese industrial policy handbook and just dumped chips on the market, just as China has done for years from solar panel manufacturing to electronics. Cheaper chips, faster chips, chips so competitive that no domestic manufacturer — even under Beijing direction — could have effectively competed. Instead we are attempting to decouple from the second largest chips market in the world, turning a competitive field where America is the clear leader into a bountiful green field of opportunity for domestic national champions to usurp market share and profits.
There were of course other goals outside of economic growth for restricting China’s access to chips. America is deeply concerned about the country’s AI integration into its military, and it wants to slow the evolution of its autonomous weaponry and intelligence gathering. Export controls do that, but they are likely to come at an extremely exorbitant long-term cost: the loss of leadership in the most important technological development so far this decade. It’s not a trade off I would have built trade policy on.
The life and death of air conditioning
Photo by Ashkan Forouzani on Unsplash
Across six years of working at TechCrunch, no article triggered an avalanche of readership or inbox vitriol quite like Air conditioning is one of the greatest inventions of the 20th Century. It’s also killing the 21st. It was an interview with Eric Dean Wilson, the author of After Cooling, about the complex feedback loops between global climate disruption and the increasing need for air conditioning to sustain life on Earth. The article was read by millions and millions of people, and hundreds of people wrote in with hot air about the importance of their cold air.
Demand for air conditioners is surging in markets where both incomes and temperatures are rising, populous places like India, China, Indonesia and the Philippines. By one estimate, the world will add 1 billion ACs before the end of the decade. The market is projected to before 2040. That’s good for measures of public health and economic productivity; it’s unquestionably bad for the climate, and a global agreement to phase out the most harmful coolants could keep the appliances out of reach of many of the people who need them most.
This is a classic feedback loop, where the increasing temperatures of the planet, particularly in South Asia, lead to increased demand for climate resilience tools like air conditioning and climate-adapted housing, leading to further climate change ad infinitum.
Josh Wolfe speaking at Nvidia Auditorium at Stanford. Photo by Chris Gates.
Josh Wolfe gave a talk at Stanford this week as part of the school’s long-running Entrepreneurial Thought Leaders series, talking all things Lux, defense tech and scientific innovation. The .
Lux Recommends
As Henry Kissinger turns 100, Grace Isford recommends “Henry Kissinger explains how to avoid world war three.” “In his view, the fate of humanity depends on whether America and China can get along. He believes the rapid progress of AI, in particular, leaves them only five-to-ten years to find a way.”
Our scientist-in-residence Sam Arbesman recommends Blindsight by Peter Watts, a first contact, hard science fiction novel that made quite a splash when it was published back in 2006.
Mohammed bin Rashid Al Maktoum, and just how far he has been willing to go to keep his daughter tranquilized and imprisoned. “When the yacht was located, off the Goa coast, Sheikh Mohammed spoke with the Indian Prime Minister, Narendra Modi, and agreed to extradite a Dubai-based arms dealer in exchange for his daughter’s capture. The Indian government deployed boats, helicopters, and a team of armed commandos to storm Nostromo and carry Latifa away.”
Sam recommends Ada Palmer’s article for Microsoft’s AI Anthology, “We are an information revolution species.” “If we pour a precious new elixir into a leaky cup and it leaks, we need to fix the cup, not fear the elixir.”
I love complex international security stories, and few areas are as complex or wild as the international trade in exotic animals. Tad Friend, who generally covers Silicon Valley for The New Yorker, has a great story about an NGO focused on infiltrating and exposing the networks that allow the trade to continue in “Earth League International Hunts the Hunters.” "At times, rhino horn has been worth more than gold—so South African rhinos are often killed with Czech-made rifles sold by Portuguese arms dealers to poachers from Mozambique, who send the horns by courier to Qatar or Vietnam, or have them bundled with elephant ivory in Maputo or Mombasa or Lagos or Luanda and delivered to China via Malaysia or Hong Kong.”
