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Podcast Archive

The Orthogonal Bet: Using Computational Biology to Understand How the Brain Works

Evolved Technology: Why technology is counter-intuitively pushing us back to natural products in pharma development

The Orthogonal Bet: The Quest to Find the Poetic Web

The Orthogonal Bet: What the Microsoft Outage Reveals

Pivoting to the Expert Economy

The Orthogonal Bet: What AI Can Learn from Human Cognition

Can we be optimistic about America’s future?

The Orthogonal Bet: Unveiling the Complexity of Life: A Conversation with Philip Ball on ‘How Life Works'

“The commons are under attack” from TikTok and subsea cables to data centers and elections

The Orthogonal Bet: How to fund R&D that is for the public good?

Is AI killing journalism? Pitchforks, Perplexity and reporters yelling “Boo!”

The Orthogonal Bet: SimCity, Maxis and the ambitious modeling of everything

Why high-throughput bio research needs better tools immediately

The Orthogonal Bet: Novelist Robin Sloan’s Love for Books with Maps on the First Page

Samuel Arbesman, PhD

How Applied Intuition used the Valley’s hardest lessons to upgrade automotive with autonomy

Orthogonal Bet: A technology vibe shift from utopian Star Trek to absurdist Douglas Adams?

Samuel Arbesman, PhD

The soon-to-be-solved protein problem that will accelerate drug discovery

Margaret Mead and the psychedelic community that theorized AI

The nightmare specter of designer bioweapons and the people trying to stop them

Lux and the Art of Startup Maintenance

The Zone of Totality with Sam Arbesman

Biology is becoming engineering and not just science

The three revolutions in astrobiology and the search for extraterrestrial life

February 21, 2024

“I am basically a cosmic Fluke” and the chaos of science, policy, and human narratives

February 14, 2024

How an anonymous blog during the neural network winter led to Japan’s national AI champion

February 8, 2024

The most wasteful infrastructure megaproject that wasn’t

February 2, 2024

The stove hasn’t changed in decades. It’s time to upgrade.

January 24, 2024

Why a Mars settlement could never be a libertarian paradise (Zach Weinersmith, Part 2 of 2)

January 24, 2024

Astronauts all lie, but the biggest lie is that we will colonize Mars (Zach Weinersmith, Part 1 of 2)

January 17, 2024

How Impulse Space’s Helios will democratize access to Earth’s farthest orbits

January 16, 2024

Why Tokyo’s Sakana AI is pioneering a new vanguard of national AI foundation models

December 21, 2023

WTF Happened in AI in 2023?

December 15, 2023

Eliot Peper's new novel 'Foundry' and the Future

December 8, 2023

The Consciousness Winter with Erik Hoel

December 1, 2023

Techno-Pragmatism: Looking Beyond Blind Optimism and Hopeless Pessimism

September 18, 2023

Navigating the Crossroads: Technology, Democracy, and National Security with Miles Taylor

September 5, 2023

The Unseen Forces Shaping America's Labor Market

August 30, 2023

Lt. Gen. Jack Shanahan on rebuilding trust between Silicon Valley and the Pentagon

August 24, 2023

AI, Bioweapons, and the Future of Warfare

August 18, 2023

Simulating Evolution: Playing God or the Next Frontier?

August 11, 2023

How many creators will survive generative AI?

We need to go deeper with the inception of deep geothermal energy

The Science of Survival: Adapting Human Life for Other Planets

How America builds the most expensive factories in the world

The p-zombie theory of consciousness

Fertility Rules from wildfire sperm death and microplastics to the potential of AI with investor Leslie Schrock

The whiplash demands of American defense manufacturing

The rising apogee of the space economy

“There are more astronauts alive than there are perfumers”: the complex supply chains of scents

“It subverts the structure even of other stories that are told about creation”

“Smell can be art, and it also can be science”: AI/ML and digital olfaction

How exponentials on top of exponentials in single-cell analysis is transforming biology today

First impressions of OpenAI’s new GPT-4 AI model

Chatphishing, veracity and “two years of chaos and a reset”

May the AI be ever in your favor

February 10, 2023

Gary Marcus on AI and ChatGPT

January 27, 2023

Why quitters are heroes with “Quit” author Annie Duke

October 20, 2022

“I have three girls; the second one is bionic”

October 12, 2022

We will observe a battle for the true openness in AI

October 5, 2022

There’s always been a global race to develop chip technology

September 30, 2022

Perhaps our greatest achievement is not being present

September 27, 2022

Web3 is so far behind in terms of reliability and security

September 21, 2022

How to recapitalize America’s bloated defense industrial base

September 16, 2022

The utopian visions of Stanford’s generations of entrepreneurs

September 11, 2022

The geopolitics and digital future of agricultural commodities

August 23, 2022

Reputations are always a trailing indicator of truth

August 17, 2022

Crypto and incentive design with MIT Cryptoeconomics Lab’s Christian Catalini

VC 101: the denominator effect

How new communities are propelling the future of tech + bio

Maybe the world is effing amazing and I am just reading the wrong things

How heath tech startups are responding to the post-Roe world

The United States has never won a conflict with the hardware that it had going into it

How will AI art generators affect human creativity?

Shoving the rocket into space with your bare hands

Vaporware skepticism

Lazy tech analogies

Alternate Histories and GPT-3

Marginal Stupidity

The ESG Mirage

Jonathan Haidt on American structural stupidity and the post-Babel world (Parts 1 & 2)

Speculative fiction is a prism to understand people

Will Malthus or human ingenuity win out in these chaotic times?

Tony Fadell on "If you’re not solving for pain, then what the hell are you doing?"

Risk, Bias and Decision Making

Shredding the endowment investing playbook playbook with Scott Wilson, CIO of Washington University in St. Louis

The future of biotech is moving from bench to beach

Chip demand and the future of the climate with Mythic AI’s Mike Henry

Redlines for diplomacy and business with former USSOCOM commander Tony “T2” Thomas

The VC Power Law with CFR senior fellow Sebastian Mallaby

Is web3 really just looking for Web 2.5?

Josh Wolfe on “There will be chaos, and that chaos will be caused by people”

Rethinking the science of science funding with Sam Arbesman

Silicon Valley’s dependence on American foreign policy

A Pod is Born, Alife is Funded, and A Decade is Defined

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